Protein Details: Glutamate receptor 3.6

Protein ID

ICDB_Pro_1193

Protein Name

Glutamate receptor 3.6

Gene Name

GLR3.6; At3g51480; F26O13.120

Organism

Arabidopsis thaliana (Mouse-ear cress)

Length

903 amino acids

AlphaFoldDB

AF-Q84W41-F1-model_v4.pdb

Function

Glutamate-gated receptor that probably acts as a non-selective cation channel. Mediates leaf-to-leaf wound signaling. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells.

Sequence

MKWFLLMLIICNAVPLQGLTKIVSARPQVVNIGSVFTFNSLIGKVIKVAMDAAVEDVNASPSILNTTTLRIIMHDTKYNGFMSIMEPLQFMESETVAIIGPQRSTTARVVAHVATELKIPILSFSATDPTMSPLQFPFFIRTSQNDLFQMAAIADIVQFYGWREVVAIYGDDDYGRNGVAALGDRLSEKRCRISYKAALPPAPTRENITDLLIKVALSESRIIVVHASFIWGLELFNVARNLGMMSTGYVWIATNWLSTIIDTDSPLPLDTINNIQGVITLRLHTPNSIMKQNFVQRWHNLTHVGLSTYALYAYDTVWLLAQAIDDFFKKGGNVSFSKNPIISELGGGNLHLDALKVFDGGKIFLESILQVDRIGLTGRMKFTSDRNLVNPAFDVLNVIGTGYTTIGYWFNHSGLSVMPADEMENTSFSGQKLHSVVWPGHSIKIPRGWVFSNNGRHLRIGVPNRYRFEEVVSVKSNGMITGFCVDVFIAAINLLPYAVPFELVAFGNGHDNPSNSELVRLITTGVYDAGVGDITIITERTKMADFTQPYVESGLVVVAPVRKLGSSAMAFLRPFTPQMWLIAAASFLIVGAVIWCLEHKHNDEFRGPPRRQVITTFWFSFSTLFFSHRETTTSNLGRIVLIIWLFVVLIINSSYTASLTSILTVHQLSSPIKGIETLQTNHDPIGYPQGSFVRDYLIHELNIHVSRLVPLRSPEEYDKALRDGPGKGGVAAVVDERAYIELFLSNRCEFGIVGQEFTKNGWGFAFPRNSPLAVDVSAAILQLSENGDMQRIRDKWLLRKACSLQGAEIEVDRLELKSFWGLFVVCGVACVLALAVYTVLMIRQFGQQCPEEAEGSIRRRSSPSARIHSFLSFVKEKEEDAKARSSRERQLEDISANGSSRCN

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed predominantly in roots and siliques

DOI ID

10.1038/35048706; 10.1111/tpj.13415; 10.1126/science.1088305; 10.1126/science.292.5521.1486b; 10.1093/oxfordjournals.molbev.a004165; 10.1038/nature12478

RefSeq

NP_001326369.1; NP_190716.3